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Tuesday, July 19, 2022

KEEPING ACTIVE FOR BETTER COGNITION: Sharpening the mind, Feeling better with ginkgo biloba

 

Prof Dr Badrisyah Idris

 

“Without the right energy and nutrients, the brain will start losing its function.”

ACCORDING to the World Health Organization (WHO), approximately 70% of the global burden of neurological and neurodevelopmental conditions affect lowand middle-income countries. Neurological conditions are the leading cause of disability and the second leading cause of death in the world with nine million deaths annually.

Stroke, migraine, dementia, meningitis and epilepsy are the top five contributors of neurological disabilities globally, with an increase in ageing populations, Alzheimer’s disease and Parkinson’s disease becoming more significant.

MSU Medical Centre’s medical director and consultant neurosurgeon Prof Dr Badrisyah Idris explains, “The brain is a unique organ with three important functions that affect our lives which are, (i) sensory interpretation and movement control; (ii) cognitive, mental and emotional integrity; and (iii) behaviour and social execution.” 

 

Prof Dr Badrisyah Idris

Brain health is becoming an important concept in healthy living which encompasses the ability of the brain to rewire during the life in response to changes in experience and environment. A healthy brain is capable of slowing down cognitive decline and combating any injury or diseases of the brain. There are a number of things that we can make a habit of to maintain our brain health.

Regular physical activity can benefit the brain by optimising brain blood flow and reducing loss of brain cells during ageing. Those who exercise regularly can enjoy healthy cognitive abilities and have a lower risk of developing dementia. Exercise also helps lower blood pressure, reducing cardiovascular risks of getting a stroke.

Some studies have found that regular exercise increases the level of protein that promotes growth and maintenance of brain cells. Having an active lifestyle such as taking the stairs and participating in sports or physical activities such as brisk walking or aerobic training can have a positive impact on brain health.

Quality sleep is important for brain healing and restoration of mental function. Sleep makes our thinking processes sharp and focused with better decision-making. Seven to eight hours of sleep gives the brain adequate time to clear abnormal proteins that accelerate dementia. Several lifestyle measures can be adopted to ensure no alteration in sleep patterns such as increasing time in the sunlight, consistent sleep routines and gaining knowledge about the effects of medications.

Even though the brain is only 2% of the body weight, it consumes 20% of energy requirements. Without the right energy and nutrients, the brain will start losing its function. Food which is rich with antioxidants (compounds that have a protective effect on the brain), fibre, unsaturated fats (including omega-3 fatty acids), B vitamins and an adequate amount of complex carbohydrates are important to maintain a healthy brain. A diet rich in processed foods, salt and refined sugars can increase inflammation and free radicals in our body that can have negative impacts on brain health.

Cognitive stimulation by learning new skills or knowledge maintain good brain health with the formation of new circuits between brain cells. Challenging the brain increases its cognitive reserve by creating an adequate backup system. With more reserves, the brain can become more resistant to changes that are associated with neurodegenerative diseases. Education and learning enhance the cognitive reserve which makes the brain less susceptible to the effects of age and brain-related changes.

Depression and anxiety can be detrimental to brain health with their effects on mood and emotion. These conditions lead to slow thinking, memory and concentration difficulties. Social connectivity helps get rid of depression and anxiety. Socialising helps the brain to expand its cognitive reserve. Engaging in conversation trains the brain to increase attention and concentration and helps social judgement. It is important to stay connected with friends and family to maintain healthy brain function. - Star2 

 

Sharpening the mind 

Various nutrients and vitamins are known to boost brainpower and help people reach their full potential.

 

LIVING in a fast-paced environment, you may find yourself juggling multiple tasks at the same time and having a constant drive to maintain momentum. The ever-increasing demands can really take a toll on you, both physically and mentally, leaving you feeling exhausted, overwhelmed or emotionally drained. If you find yourself having moments of spacey or fuzzy thoughts, you are most likely experiencing brain fog.

Brain fog has become more common than ever before as a result of hectic lifestyles. Also known as mental fatigue, it is not a medical condition but rather a cognitive dysfunction involving an inability to focus, poor concentration, forgetfulness, confusion, irritability, headaches, etc.

Brain fog can come and go over a period of time, commonly triggered by stress, lack of sleep, hormonal changes, nutrient deficiencies, or medications. More than just a nuisance, these challenges can damper your mental clarity and interfere with your ability to complete daily tasks at varying degrees. If left unaddressed, it can snowball into chronic fatigue which ultimately leads to burnout.

Nootropics are known to help boost brainpower so you can perform at your fullest potential, whether you are a student aiming to ace your exams, a working professional striving to excel at your duties or a senior looking to preserve your grey matter.

Acetyl-l-carnitine is an amino acid produced naturally in your body. It supports cellular energy production to fuel your brain for better focus and concentration. As an antioxidant, it helps protect brain cells from oxidative stress.

Vitamin B12 is an essential vitamin for proper development and functioning of the brain and nervous system. It supports the formation of myelin sheath which protects* the nerve cells, ensuring fast and effective transmission of nerve impulses. It is also required to produce mood-enhancing dopamine and serotonin.

Phosphatidylserine is an essential building block of cell membranes, with high concentrations in the nerve cells of the brain. It increases the production of acetylcholine, an abundant neurotransmitter in the brain, which plays an important role in alertness, learning and memory.

Together, these nutrients work synergistically to give you an extra boost to get you through the busy day.

This informational article is brought to you by Vitahealth.

■ For more information, call 1800 183 288. 

Gear up
 

 

Feeling better with ginkgo biloba 

 


THE ginkgo biloba is a tree native to China that has been historically associated to have traditional medicinal properties that help reduce memory loss, aid respiratory difficulties and improve circulation. Sometimes known as the maidenhair tree, it is often described as a ‘living fossil tree’ due to its ancient taxonomic origins dating to prehistoric times.

In more recent years, ginkgo extract has been discussed as a prescription to help alleviate symptoms of anxiety as well as to improve cognitive function related to mental disorders such as Alzheimer’s disease. According to Herbs and Botanical Supplements: Principles and Concepts by Nutrition in the Prevention and Treatment of Disease, the extract has been approved as a treatment for dementia in countries such as Germany.

According to Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders published by Neurotherapeutics, ginkgo is linked with improved cerebral blood flow which may be beneficial in reducing fatigue and absent-mindedness. In addition, ginkgo biloba was also shown to have neuroprotective effects through several in-depth clinical studies.

In a research titled Ginkgo biloba special extract EGB 761® in generalised anxiety disorder and adjustment disorder with anxious mood: A randomised, double-blind, placebo-controlled trial published by Journal of Psychiatric Research, individuals with a generalised anxiety disorder who had participated in the study were found to experience improved anxiety relief when compared to the group who had taken a placebo.

Ginkgo biloba has also been linked with improving several cognitive functions that are associated with Alzheimer’s Disease, as reported by The Efficacy of Ginkgo biloba on Cognitive Function in Alzheimer Disease published in Neurological Review reports.

A placebo-controlled, double-blind, randomised trial of an extract of Ginkgo biloba for dementia by the Journal of the American Medical Association suggests further evidence for the soothing effects of ginkgo biloba in cases of dementia. Within its intent-to-treat analysis, researchers found that the participants who were given ginkgo biloba extract scored substantially lower on the commonly used Alzheimer’s Disease Assessment Scale.

Overall, ginkgo biloba extracts can be a strong consideration when faced with issues pertaining to certain brain conditions and blood flow.

■ For more information, call 03-7490 2138. 

Nature's Way, Ginkgo, 120 Vegan Capsules

  Nature's Way, Ginkgo, 120 Vegan Capsules

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Rush for fourth shot as Covid-19 cases rise

 

Staying protected: Leow Pui Ling, 28, getting her second booster shot at iHEAL Medical Centre in Kuala Lumpur. — FAIHAN GHANI/The Star

 

PETALING JAYA: There has been a 51% increase in the number of people being vaccinated over the last two weeks, as new Omicron sub-variants create fears of another Covid-19 wave.

According to figures from ProtectHealth, vaccination went up from 38,822 during the week of June 27-July 3 to 50,774 during the week of July 4-July 10, a 31% increase.

ALSO READ:Better safe than sorry, say those getting second booster

From the week of July 11-July 17, there was a 51% increase to 76,433.

As infections and hospitalisations rise across the country, health experts are also calling for Malaysians, especially those over 60 as well as the medically vulnerable, to get their second booster shot.

This is because the Omicron sub-variants are highly contagious and can bypass immunity from a past infection or vaccination.

Public health expert Prof Dr Moy Foong Ming of Universiti Malaya said the Omicron sub-variant BA.5 could evade antibody responses in people with previous Covid-19 infection and those who had been fully vaccinated and boosted.

“Reinfections may be inevitable but boosters will help provide protection against severe symptoms, hospitalisation and even death.

“Even though the BA.5 does not seem to cause more severe symptoms compared to BA.1 and BA.2, the elderly and vulnerable groups will likely experience severe symptoms,” Prof Moy said.

She cautioned that if the total caseload increases tremendously, even with a low percentage of hospitalisation, the number will be a huge burden on the healthcare system.

“We don’t want to lose precious lives if it can be prevented,” she said.

For those below 60, it may not be necessary to take the second booster at this moment.

“If this group of individuals had received their third dose, they should be well protected from severe symptoms,” said Prof Moy.

“When new vaccines are able to bring a stronger immune response against all new variants, then a second booster may be offered to all.”

Prof Moy also said Malaysians should consider taking a flu shot if they were in the high-risk group, especially those aged 65 and above, and with chronic health conditions such as diabetes and weakened immune system.

Public health expert Prof Dr Sharifa Ezat Wan Puteh of Universiti Kebangsaan Malaysia said sub-variants BA.4 and BA.5 were known to evade immunity, hence breakthrough infections could occur.

“The risk will be reduced if you obtain another booster,” she said.

“The elderly, immunocompromised, as well as people with morbidities and frontliners should be prioritised for a second booster. But now, even those who are young and have received only two doses should get a third jab,” she said.

Prof Sharifa Ezat also reminded the public to get tested for Covid-19 and influenza if symptomatic, as these can mimic each other and it is possible to get infected with both.

“This impedes recovery. If possible, get vaccinated against both,” she said.

“The government should work on obtaining supply for flu tests and pushing the flu vaccine price down.”

Volunteers For Community Engagement and Empowerment For Covid-19 chairman Datuk Dr Zainal Ariffin Omar reminded Malaysians to continue with good personal health practices such as wearing a face mask, avoiding crowded places, self-testing and quarantining if positive with Covid-19, as well as observing a good diet. 

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Sunday, July 17, 2022

CoVarScan, new Covid-19 test can identify all variants

 

Researchers noted that the CoVarScan test detects small mutations to measure the length of repetitive genetic regions that tend to grow and shrink as the virus evolves. — Photo: US Centers for Disease Control and Prevention/dpa

 CoVarScan can identify all current variants of SARS-COV-2 within hours by finding the signatures of eight hotpots on the deadly virus.

The University of Texas (UT) Southwestern researchers have created a rapid Covid-19 test that can identify different variants of the coronavirus in as little as four hours.

The researchers hope doctors can use their test, called CoVarScan, to tailor Covid-19 treatments to patients based on which variant the patients have.

CoVarScan could also be used to track which variants are cropping up in different communities, and even identify new ones.

“It was such a pleasure and, really, an honour to be able to take this skillset, what we have, and build something that has public health utility,” said Andrew Clark, an assistant professor of pathology at UT Southwestern and an author of the study.

The research was published in the journal Clinical Chemistry recently.

Scanning for a specific variant of the SARS-CoV-2 virus is a bit different from a typical rapid test.

Dr Jeff SoRelle, an assistant professor of pathology at UT Southwestern, said a normal rapid Covid-19 test is a bit like going into a library and asking if they have a specific book.

You get a “yes” or “no” answer.

Looking for variants is like reading specific paragraphs in two similar books to figure out whether the books are in their second or third edition.

Between editions, words may be added, deleted or changed altogether.

Finding out which edition of SARS-CoV-2 someone has is usually done by a process called “whole genome sequencing,” where scientists look at the entire viral sequence – or, read the entire book – to figure out where the differences are.

That process can be expensive and takes one to four weeks to produce results.

CoVarScan works by looking at just eight regions, or hotspots, of the SARS-CoV-2 genetic sequence instead.

Each variant looks a little bit different at these hotspots.

Dr SoRelle’s team can analyse each of the regions to identify a unique pattern of mutation that’s specific to each variant.

They’ve also used CoVarScan to identify different subvariants of Omicron.

“They create unique signatures, or fingerprints, of mutations,” Dr SoRelle said. “We can really tell the difference between each of them.”

To make sure CoVarScan was getting it right, the team ran just under 4,000 samples from positive Covid-19 nasal swabs through the test. They checked CoVarScan’s results against results from whole genome sequencing.

Dr SoRelle and his team found that CoVarScan was highly effective at identifying variants correctly.

What makes CoVarScan unique is its ability to not only detect existing variants, but also detect new variants that have yet to develop.

The team began this research in January 2021, before the Delta and Omicron variants existed.

Once they know the genetic sequence of a new variant, CoVarScan can look for the variant’s unique fingerprint of mutations along with the existing ones.

“We wouldn’t necessarily need to change what we do in the testing,” he said. “Just change what we’re looking for.”

Padmapriya Banada, a research assistant professor at Rutgers University who was not involved with the study said CoVarScan’s ability to detect future variants as well as current ones is critically important.

However, one challenge in making CoVarScan more widespread is that it identifies hotspots using scientific equipment that every lab might not have.

She said more work will be necessary to implement CoVarScan at places like schools or doctors’ offices that might not have such technical equipment on hand.

“It does need some technical expertise,” Banada said. “But considering what it offers, it probably overcomes those limitations.”

CoVarScan is already provided to anyone who tests positive for Covid-19 at UT Southwestern Medical Center, and Dr SoRelle is working with Dallas County to see if CoVarScan can help hospitals track what variants are most common in their area. – TNS 

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