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Thursday, August 29, 2024

Chinese scientists discover new gene that regulates lifespan

Mechanism of action of OSER1 in lifespan regulation. (Image provided by Southwest University).

Chinese scientists have discovered a new gene, OSER1, that regulates lifespan. This breakthrough provides a novel scientific basis for the study of extending human lifespans. 

The team studied the mechanism of action in various species such as silkworms, nematodes, and fruit flies. As a target gene of the longevity gene FOXO, OSER1's impact on lifespan has been supported by human subject research results.

This breakthrough finding was made by Dai Fangyin’s team from the National Key Laboratory of Efficient Utilization of Insect Resources at Southwest University and scientists from abroad. The results have been published in the international academic journal "Nature Communications."

FOXO is one of the few confirmed human longevity genes. It affects lifespan by regulating pathways related to aging, but the targets mediating these effects are largely unknown. 

The research team conducted interference experiments on 42 potential direct target genes of the FOXO gene in silkworms, which are similar to genes in nematodes. They discovered that down-regulating the expression of 7 genes significantly shortened the lifespan of nematodes, while down-regulating 3 genes extended their lifespan. Crucially, gene OSER1 had the most significant impact on lifespan when its expression was reduced.

“OSER1 is present in the genomes of various species including nematodes, silkworms, fruit flies, zebrafish, African clawed frogs, mice, rhesus monkeys, and humans,” said Song Jiangbo from National Key Laboratory of Efficient Utilization of Insect Resource at Southwest University, who is also a co-author of the paper. 

The study revealed that increasing the expression of OSER1 in silkworms, nematodes, and fruit flies led to a significant extension of their lifespan. This discovery could have implications for understanding the aging process and potentially developing interventions to increase lifespan in other species, including humans. 

Research findings on human subjects have confirmed that OSER1 plays a role in determining the human lifespan, according to Song. The study revealed that individuals over 90 years old had 49 common single nucleotide variations in the OSER1 gene, with seven of them showing a significant link to longevity when compared to a younger control group.

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Black Myth: Wukong is an action role-playing game developed and published by Game Science. Black Myth: Wukong is available on August 20, 2024 for PlayStation 5 (PS5) and Windows (PC) with Xbox Series X/S releasing at a later date.
 
 

Rise of the Monkey King (Volume 1 of "Journey to the West") - Audiobook

China goes ape over culture-boosting Black Myth: Wukong video game.

CHINESE state media threw its back behind China’s most successful single-player video game to date, saying its adaptation of the Ming dynasty epic Journey To The West would force Western players to learn more about the country’s culture.

Black Myth: Wukong, based on a mythical monkey king from a Chinese literary classic who can shape-shift into humans, animals and inanimate objects, was being played last Wednesday by 2.2 million concurrent players on Steam, a major online gaming platform, a day after its release.

“Chinese players in the past have gone through this process of cross-cultural understanding, now it is the turn of overseas players to learn ... and understand Chinese traditional culture,” China Central Television wrote in a blog.

Drawing heavily on the story of the beloved magical monkey, Sun Wukong, who acquires supernatural powers by practising Taoism, Black Myth: Wukong can only be enjoyed if players are familiar with the plot of the 16th century classic, the national broadcaster said.

The Pc/console-based game was launched last week by Game Science, a Tencent-backed startup, to much fanfare on Chinese social media. Hashtags on the video game accumulated 1.7 billion views on China’s X-like microblog Weibo.

“This release marks a bold foray by Chinese game developers into a market long dominated by Western triple-a titles,” the official Xinhua news agency wrote in an editorial last week.

“With this breakthrough, the default language of a triple-a game is no longer English, but Chinese,” it added.

Black Myth: Wukong would “attract more global players to pay attention to domestic games”, said analysts at Shanghai-based Topsperity Securities, adding that companies across a wide range of sectors could expect to profit off intellectual property tie-ins.

Ride-hailing firm Didi, Lenovo Group and Luckin Coffee are incorporating elements inspired by Black Myth: Wukong into their promotional campaigns.

Black Myth: Wukong was widely lauded as China’s first AAA game – high development costs, long production cycles and immense investment, with industry analysts viewing its sudden fame and popularity as marking an inflection point for China’s PC/ console gaming sector.

Pre-sales, which began in June, had reached Cny400mil (Us$56mil/rm245mil) as of last Tuesday when the game was launched, according to Citi.

Feng Ji, founder of Game Science, told Xinhua in an interview that the global attention has surpassed his initial expectations and that his team would develop more of such games.

“We see signs that the government is recognising the industry’s potential value for exports and culture, notably the interview of Game Science’s founder by state media Xinhua agency ahead of its game launch,” Goldman Sachs wrote in a note.

Goldman added that it expected more Chinese AAA games to enter the global market in the future.

Be that as it may, gaming stocks were unchanged last Wednesday, with concept stocks linked to the game’s development down after having risen considerably over the past month.

Unlike other Chinese games that are played on mobile devices and involve endless in-game micro-transactions, “Black Myth: Wukong” is a one-time purchase with a price tag of CNY268 (RM165) for the standard version and CNY328 (RM200) for the premium.

“It is unclear whether Black Myth: Wukong’s business model can bring more profits ... the important thing ... is that China is finally getting it’s own AAA game that can excite the world,” stateowned tabloid Global Times cited an industry insider as saying.

“Global players will be able to get a deeper understanding of traditional Chinese culture while having fun,” Global Times declared. – Reuters

 Some Western media politicize every Chinese achievement, even 'Black Myth: Wukong'
Illustration: Chen Xia/GT

Illustration: Chen Xia/GT

Black Myth: Wukong, a video game that embodies the dream of Chinese gamers to have a game deeply rooted in Chinese culture and on par with the best games globally, has been a major hit since its debut. However, just like every success China has had, Western media's criticism is never far behind.  

Even if Western media can't deny the game's global success, there is often a classic "but" in their reports. "'Black Myth: Wukong' Is a Hit. But Why Is the Game So Controversial?" US magazine Rolling Stone asked recently, stressing that the game lacks "inclusivity and diversity." A BBC headline was entirely negative: "Blockbuster Chinese video game tried to police players - and divided the internet."

The criticism about inclusivity and diversity appears to be a rushed judgment from journalists or commentator who spent only a few hours with the game. If they played longer, they would see that female characters do appear over time. The point it, true players don't really care about it. As some overseas netizens put it - it's a game, not a movie, it doesn't need to cater to Western political correctness by including diverse female characters or transgender individuals.

The recent attacks from some Western media outlets come after Black Myth: Wukong has challenged the gaming ecosystem in the Western world, Shen Yi, a professor at Fudan University, told the Global Times. In this system, consulting firms like Sweet Baby Inc offer costly diversity, equity, and inclusion advice for video games. Black Myth: Wukong, however, not only reportedly showed no interest to obediently conform to distorted rules but also achieved unprecedented success. This has sparked both envy and fear among those who control the ecosystem and led to the recent attacks focused on gender, diversity, and inclusivity.

Moreover, the radar of some anti-China forces is triggered when Black Myth: Wukong is increasingly considered as a symbol of China's soft power, prompting foreign players to rediscover China's capabilities while promoting the global spread of traditional Chinese culture. The BBC - which cannot accept the fact that China's image is improving through the game - wrongly accuses China of censorship to dampen international perceptions of China. 

Their strategy of attacking the game is just the same old Western tactic - politicizing every Chinese achievement, even in the realm of gaming. What's next? Will they portray the Chinese gaming industry as a "threat" in the future? 

What they fail to grasp is that whether players choose to pay for a game is never about ideology, or political correctness over diversity. The game's quality is what truly matters. Feng Ji, founder of the game's developer Game Science, recently said that cultural export was not the initial goal of the game. Yet he believes that if the quality is high enough, it will naturally radiate to the overseas market. 

He made it. Black Myth: Wukong's high quality has fueled its popularity. Many international players enjoy the game, which has inspired their curiosity about Journey to the West and Chinese culture.

If Black Myth: Wukong hadn't been successful, if it hadn't topped sales charts worldwide, and if it had been just an average game, would Western media even care about it? They would probably just claim that China has no AAA game. The fact that they attack the game proves its success and highlights the persistent cultural hegemony and arrogance of some in the West. While Chinese people have long been opening up to the world, some Westerners are still unwilling to recognize China as it is.

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