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Thursday, April 27, 2023

Get booster to evade new variant: the Arcturus subvariant !

 New COVID variant causing itchy, watery eyes

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PETALING JAYA: Health experts have advised the public to take precaution amid confirmation that the Arcturus viral subvariant has been detected in the country.

Professor in Public Health Medicine and Health Economy in Universiti Kebangsaan Malaysia Dr Sharifa Ezat Wan Puteh said although the SARS-CoV-2 XBB.1.16 (Arcturus) viral subvariant is highly infectious, nothing pointed to it being more dangerous than other Omicron variants currently in circulation.

“It is advisable for people to get a booster shot if they have not received one and wear a face mask whenever in crowded spaces,” she said, adding the government will soon be offering Bivalent vaccines which are especially effective for Omicron variants.

Prof Sharifa said symptoms of the Arcturus subvariant included itchy or sticky eyes, as well as high fever and cough – particularly among children.

The Arcturus subvariant is highly infectious because it is difficult to be traced by our antibodies and because of that, it can cause people who already had Covid-19 in the past to be reinfected.

“This will cause an increase in Covid-19 cases in time to come, and the World Health Organisation has classified the Arcturus subvariant as a ‘variant of interest’ (VOI) that will be under careful observation,” she added.

Public Health Medicine Specialist Datuk Dr Zainal Ariffin Omar said the subvariant was fairly new and not much details was known about it so far.

“It is predicted to be more infectious and may cause a rise in cases, but regardless, people should be vigilant and follow the SOP including masking up and getting a booster shot,” he said.

Professor of Epidemiology and Public Health in Universiti Malaya Prof Dr Moy Foong Ming said Arcturus was the dominant variant in India and causing a new wave but added that cases were mostly with mild symptoms.

According to WHO, while this variant seems to be spreading faster and escapes immunity, it does not seem to be causing more severe illness in individuals or in the population infected with Arcturus.

“However, even though it is not more lethal than other Omicron subvariants, we should take it seriously as it may cause severe illness to vulnerable groups,” she said.

Prof Moy said whether a variant will cause a wave in a country depended on the immunity of the population as well as the variant which was last dominant there.

The public should practice TRIIS: Test, Report, Inform, Isolate and Seek medical help if infected.

“Those who do not have their vaccination up to date and have not taken a booster dose should do so as soon as possible,” she said.

On Monday, Health Minister Dr Zaliha Mustafa said a total of 12 cases involving the Arcturus viral subvariant had been detected in the country.

Six cases were detected in Sarawak, four in Selangor and two in Kuala Lumpur, she said.

The XBB.1.16 subvariant was first detected in the country in March, but the minister said the situation was under control and that health facilities were not under any pressure. 

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Monday, April 24, 2023

Important to mark DNA Day, crucial for discovery of the genome’s sequence

 

photo: afp relaxnews

EVERY year on April 25, the global scientific community unite to celebrate DNA Day, marking the momentous completion of the human genome project in 2003 and the discovery of the double helix in 1953.

On April 25, 1953, James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin and colleagues published papers in the journal Nature on the structure of DNA. By commemorating DNA Day, scientists and enthusiasts seek to emphasise the significance of DNA research and inspire future generations to pursue advancements in genetics.

DNA is like a recipe book for living things; it stores vital information that is passed down from one generation to the next. The information is stored in the form of genes that determine the characteristics of an organism, and is protected and held in place by chromosomes. In humans, the genome is made up of approximately three billion base pairs of DNA. Studying the genome and its variations can therefore provide insights into the causes of genetic disorders and help researchers develop new treatments.

DNA holds significant potential in the fields of medicine, anthropology and forensics. In forensics, DNA is frequently used to determine the guilt or innocence of suspects as well as to identify unknown deceased individuals, by analysing DNA collected from hair, skin or blood samples. DNA can also be used to trace a person’s ancestry and determine their ancestral homeland.

In medicine, genetic testing can identify mutations in a person’s DNA that increase his/her risk of developing certain diseases, such as breast or ovarian cancer. DNA sequencing can also help doctors develop personalised treatment plans for patients with cancer or other diseases by identifying specific genetic mutations driving the disease’s growth. In some cases, DNA testing can also diagnose rare genetic diseases that might be difficult to identify otherwise.

Additionally, newborns can be screened for certain genetic conditions that may not be apparent at birth, allowing for early interventions or treatments that can improve outcomes for them.

Precision medicine is an advanced approach that considers the individual characteristics of each patient, in particular their genetic profile. This approach has the potential to revolutionise scientific and medical progress and improve the health of families by providing doctors with the resources to identify specific treatments for various illnesses.

Historically, most medical therapy development has focused on the “average patient” using a “one-size-fits-all” approach to treatment. While this may be beneficial for some individuals, it can be completely ineffective for others. With precision medicine, doctors can develop tailored treatments that are customised to a patient’s specific needs, leading to more effective and personalised care.

That’s why it’s so crucial for us to have a full picture of the human genome, and why the discovery of the genome’s sequence was welcomed by academics and doctors everywhere.

As our knowledge of DNA and the information it encodes grows, we may one day live in a society with fewer and better-managed diseases, longer lifespans, and individualised medical care rather than mass-produced pharmaceuticals designed for the general population.

- PROF ZILFALIL ALWI, ABDUL HALIM FIKRI HASHIM and NOR RAFIDA MOHD SENI Universiti Sains Malaysia, Kelantan

Prof Zilfalil heads the Malaysian Node of the Human Variome Project and is also Unesco Chair in Human Genetics on Thalassaemia, a programme that involves over 850 institutions across 117 countries. 

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Saturday, April 22, 2023

Malaysian Scientist in Tsinghua leads space stem cell research at top varsity

 

Prof Dr Kee Keh Hooi from the School of Medicine, Tsinghua University in Beijing.

 Kehkooi Kee-School of Medicine, Tsinghua University 

https://www.med.tsinghua.edu.cn/en/info/1352/1446.htm

Guest: Prof Dr Kee Keh Kooi (Scientist, Tsinghua University)

Kampung boy leads space stem cell research at top varsity 

KUALA LUMPUR: It may seem like a galaxy far, far away when human beings from earth can stay for a long period of time in a spacecraft or even on the moon or Mars, but Malaysian scientist Prof Dr Kee Keh Kooi is already doing research on its effects on human bodies.

The Tsinghua University lecturer is heading a team to study how gravity and even radiation affect the development of human embryonic stem cells in space.

In short, understanding how human reproduction will affect human beings who will spend a long time in space.

The research is also to find answers as to how the human embryonic stem can differentiate in space.

“It is already happening as Chinese astronauts could stay for a period of time in a station on the moon, astronauts could orbit around the earth, and even ordinary people could travel to space,’’ he said.

The Sitiawan-born renowned academician was interviewed online from Beijing by Star Media Group adviser Datuk Seri Wong Chun Wai on his webcast programme @realchunwai on Thursday.

His accomplishment was highlighted by Prime Minister Datuk Seri Anwar Ibrahim when he spoke at Tsinghua University during an official visit to China last month.

China recently announced its readiness to start its lunar base on the moon within five years, ahead of landing astronauts there in subsequent years.

Dr Kee has also conducted his research via China’s first cargo spacecraft, Tianzhou-1, which was launched in 2017.

Its main task was to deliver fuel and supplies to the orbiting Tiangong 2 space lab, but it also played host to ground-breaking scientific experiments conducted remotely by earth-based scientists in China.

Dr Kee specialises in stem cell research and how it can be cultured for medical technologies to help patients suffering from Parkinson’s and Alzheimer’s diseases and even spinal cord injuries.

Besides devoting his time in laboratories, he also lectures undergraduate and post-graduate students at Tsinghua, which is regarded as China’s top university.

He spent decades in the United States, where he obtained bachelor’s and master’s degrees at Iowa State University. This was followed by a PhD at Weill Cornell University.

Later, he worked at the University of California, San Francisco, before taking up a three-year stint as a research associate at Stanford University.

The opportunity for him to take a leading role as a principal researcher came when he applied for a post at Tsinghua University after seeing a vacancy advertised in an academic journal in 2009.

“There was an opening for stem cell research at the university, and it caught my interest immediately,’’ he said.

Asked about the differences in the manner in which research is conducted in China and the United States, Dr Kee said that in the United States, individual research was common, while in China, a team of between 50 and 100 people could be involved in a big project.

Despite having spent over 12 years in Beijing, Dr Kee, who grew up in Johor Baru, makes it a point to visit Malaysia annually, especially during Chinese New Year.

His parents, who moved to Johor Baru from Sitiawan to run a coffee shop, are still operating at the premises in Gelang Patah.

Dr Kee is a former student of Foon Yew High School, one of the elite independent schools in Johor.

“Balik kampung is always on my mind. The minute China reopened its border, I took my family home to Malaysia for three weeks,” he said.

Dr Kee, who was born in Kampung Remis, a small fishing village, described himself as a kampung boy. His family, he said, is “a simple Teochew family”.

Dr Kee said he would be happy to conduct talks on his work at Malaysian universities if there are opportunities.

His advice to Malaysians who wish to study at Tsinghua or Peking University is simply to study hard, get good grades and be focused.

However, he added that there are many other universities in China besides these top two.

He said Tsinghua also offers other disciplines, especially at the post-graduate level in economics, architecture, and law, which are conducted in English for international students.

To watch the full interview with Dr Kee, follow @realchuwai on Facebook and YouTube. 

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